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Here is what they contain, side by side with the doses that clinical studies actually used: The dosing gap is the core problem

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ENO1 Silencing Impaires Hypoxia-Induced Gemcitabine Chemoresistance Associated With Redox Modulation in Pancreatic Cancer Cells

Defects in CI are among the most common causes of mitochondrial disorders and have been linked to a wide range of pathologies, including neurodegenerative and cardiac diseases 28